Ractions which we are able to use
Acylation
acetylation of aromatic compound - acetylbiphenyl, acetylnaphtalene, acetyltoluene...
acylation of amines - acylanilides...
acylation of ureas - acylphenylurea...Alkylation
alkylation of aromatic compound - terc.butyltoluene, terc.butylnaphtalene, alkyltoluenes, alkylphenoles...Esterification
esterification of acids - esteres of mandelic acid...
monoesteres of dicarboxylic acids
estereres of hydroxyacids
esterification of aminoacids - esteres of glycine, alanine, lysine, aspartic acid...
partial esterification of polyfunctinal alcohols-esteres of glycerol, pentaerythritol, glycolReduction
by complex hydrides - reduction of ketones, esteres, laktones
by zinc - reduction of chloroderivatives, nitroderivatives
by hydrogen(Pd,Rh) - reduction of duble bound (atmospheric conditions)
Meerwein-Ponndorf reaction
with transfer of hydrogen-reduction by formic acid, formaldehyde...Oxidation
by chrome oxide and chrome compounds - preparation of aldehydes, acids
by manganese dioxide - preparation of aldehydes
by selenium dioxide - preparation of aldehydes, ketones
by permanganate - preparation of alcohols
by RuO4, hydrogen peroxide, periodate, iodate
Epoxidation
by peracids - epoxidation of olefins, terpens...
by hydroperoxides - epoxidation duble boundsHalogenation
preparation of carboxylic chlorides and sulphonic chlorides - chloride of mandelic acid, benzyloxyacetic acid ( benzyloxyacetyl chloride )...
bromation by bromine, by N-bromosuccinimide, phosphorus bromide - bromoderivatives of aromatic compounds
iodation - iodalkanesWittig, Grignard, Prins, Vielsmeier reaction, Malonesteric synthesis...
Preparation of optically active compounds
enzymatic separation
kynetic separation
separation by optically active aminesSamples of multistage synthesis:
preparation of prostaglandines - Misoprostole, PGF, PGE...
preparation of heterocyclic compounds - Aminochlorine, Xantin, Hypoxantin, Uracil, Furfurylaminopurin, Kinetin...
preparation of calixarenes - Calix[4]arene, Calix[6]arene, Calix[8]arene and their derivatives...
preparation of acetylcholinesterase reactivators - derivatives of pyridinium aldoxime